After escaping from prison, Lincoln Burrows & Michael Scofield are on the run with one goal in mind clear Lincoln´s name and uncover the hidden $5 million.
Over the wall and on the lam, the most-wanted men in America, Michael Scofield (Miller) and his brother Lincoln Burrows (Purcell), must lead a dangerous band of hardened fugitives on a desperate international flight, chasing millions of dollars, risking everything to expose a sinister government conspiracy, and fighting desperately to stay alive until the day they can stop running. Wanted, hunted, betrayed, and double-crossed, the Fox River Eight are out of prison and on the run in the explosive and unpredictable second season of "Prison Break", and this time, not everyone makes it out alive!..